Biomarkers of kidney injury

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Biomarkers of acute kidney injury.

Creatinine remains the standard for laboratory diagnosis of AKI. Efforts to prevent nephrotoxicity have been harmed by the delay in the diagnosis of AKI criteria by using only the creatinine as a marker, therefore there is great interest in identifying early reliable biomarkers. Moreover, early treatment of ARF can be correlated with a better prognosis and identification of biomarkers for early...

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Biomarkers of Acute Kidney Injury

The diagnosis of acute kidney injury (AKI) is usually based on measurements of blood urea nitrogen (BUN) and serum creatinine. BUN and serum creatinine are not very sensitive or specific for the diagnosis of AKI because they are affected by many renal and nonrenal factors that are independent of kidney injury or kidney function. Biomarkers of AKI that are made predominantly by the injured kidne...

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Biomarkers in Acute Kidney Injury

Introduction Acute Renal Failure (ARF) remains a common and signifi cant problem in modern medicine. The epidemiology and causes of ARF vary according to the clinical setting; in intensive care units it is estimated that the incidence of ARF ranges from 10%–25%,1,2 with acute tubular necrosis (ATN) accounting for about 75% of cases.3 Recent data from the BEST kidney investigators has estimated ...

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Biomarkers in Acute Kidney Injury

Acute kidney injury (AKI) is one of the popular topics of discussions due to increasing development of biomarkers recently. The disease progression and prognosis may be determined by these biomarkers detected in blood and urine specimens. Since acute kidney injury is associated with a broad spectrum of disease conditions, prevention and early detection of AKI becomes very important in those cli...

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ژورنال

عنوان ژورنال: Biomarkers

سال: 2011

ISSN: 1354-750X,1366-5804

DOI: 10.3109/1354750x.2011.587129